Original Article

THERAPEUTIC EFFECTS OF rhTNF ALONE AND IN COMBINATION WITH KENGSHENGMYCIN IN EXPERIMENTAL HUMAN OVARIAN CANCER

Enfeng Zhao, Meiqing Zhou, Caiying Fu, Beifen Shen, Quan Zhang, Lijuan Lian

Abstract

Based on experiments in vitro, we examined the therapeutic effect of rhTNF both alone and in combination with Kengshengmycin (KSM) on human ovarian cancer transplanted in nude mice. The results showed a considerable antitumor effect of rhTNF when it was used alone and a marked synergistic effect when it was used in combination with KSM on the xenograft tumors.