Original Article
AUGMENTATION OF IMMUNE FUNCTIONS AND AUTOLOGOUS TUMOR-KILLING ACTIVITY BY KAPPA-SELENOCARRAGEENAN IN MICE BEARING SARCOMA 180
Abstract
Objective: To study the enhancement of the immune functions and autoiogous tumor-killing (ATK) activity by kappa-selenocarrageenan (KSC) in mice bearing sarcoma 180.
Methods: To measure the effects of KSC and/or Cyclophosphamide (Cy) on natural killer (NK) activity, lymphokine-activated killer (LAK) activity, the production of interleukin-2 (IL-2), ATK activity and the growth of sarcoma 180 (S180).
Results: KSC promoted NK activity, LAK activity and ATK activity in vivo, increased IL-2 production at 40 mg/kg/dx9d. It also enhanced the antitumor action of Cy (20 mg/kg/dx9d) and offset the inhibition of Cy on immunocopetent cells. The ATK activity in splenocytes of Sls0-bearing mice could be induced and increased by recombinant interleukin-2 (rlL-2) in vitro.
Conclusion: KSC has an up-regulating effect on the immune functions and ATK activity in tumorbearing mice. It can be used as a biological response modifier (BRM) in cancer biotherapy.
Methods: To measure the effects of KSC and/or Cyclophosphamide (Cy) on natural killer (NK) activity, lymphokine-activated killer (LAK) activity, the production of interleukin-2 (IL-2), ATK activity and the growth of sarcoma 180 (S180).
Results: KSC promoted NK activity, LAK activity and ATK activity in vivo, increased IL-2 production at 40 mg/kg/dx9d. It also enhanced the antitumor action of Cy (20 mg/kg/dx9d) and offset the inhibition of Cy on immunocopetent cells. The ATK activity in splenocytes of Sls0-bearing mice could be induced and increased by recombinant interleukin-2 (rlL-2) in vitro.
Conclusion: KSC has an up-regulating effect on the immune functions and ATK activity in tumorbearing mice. It can be used as a biological response modifier (BRM) in cancer biotherapy.
