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AUGMENTATION OF IMMUNE FUNCTIONS AND AUTOLOGOUS TUMOR-KILLING ACTIVITY BY KAPPA-SELENOCARRAGEENAN IN MICE BEARING SARCOMA 180

   
@article{CJCR1942,
	author = {Hulai Wei and Zhengping Jia and Huishun Zhao},
	title = {AUGMENTATION OF IMMUNE FUNCTIONS AND AUTOLOGOUS TUMOR-KILLING ACTIVITY BY KAPPA-SELENOCARRAGEENAN IN MICE BEARING SARCOMA 180},
	journal = {Chinese Journal of Cancer Research},
	volume = {10},
	number = {3},
	year = {2013},
	keywords = {},
	abstract = {Objective: To study the enhancement of the immune functions and autoiogous tumor-killing (ATK) activity by kappa-selenocarrageenan (KSC) in mice bearing sarcoma 180. 
Methods: To measure the effects of KSC and/or Cyclophosphamide (Cy) on natural killer (NK) activity, lymphokine-activated killer (LAK) activity, the production of interleukin-2 (IL-2), ATK activity and the growth of sarcoma 180 (S180). 
Results: KSC promoted NK activity, LAK activity and ATK activity in vivo, increased IL-2 production at 40 mg/kg/dx9d. It also enhanced the antitumor action of Cy (20 mg/kg/dx9d) and offset the inhibition of Cy on immunocopetent cells. The ATK activity in splenocytes of Sls0-bearing mice could be induced and increased by recombinant interleukin-2 (rlL-2) in vitro. 
Conclusion: KSC has an up-regulating effect on the immune functions and ATK activity in tumorbearing mice. It can be used as a biological response modifier (BRM) in cancer biotherapy.},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/1942}
}