Review Article

The benign mimickers of prostatic acinar adenocarcinoma

Yuqiao Xu, Yingmei Wang, Ru Zhou, Haiyang Li, Hong Cheng, Zhe Wang, Jing Zhang


As the most frequent malignant histological subtype in prostatic cancer, prostatic acinar
adenocarcinoma (PAA) has a series of benign mimickers including prostatic or non-prostatic lesions
and normal structures, which may lead to an erroneous diagnosis and inappropriate treatment. It is very
important to be aware of the existence of these mimickers and to recognize their histological features.
The differential diagnosis should be based on a comprehensive evaluation of clinical history, histological
structure, cytological morphology and the results of immunohistochemistry (IHC) staining, rather than on
single criteria (e.g., the presence of prominent nucleoli or basal cell layer).