THE EFFECT OF HYPO - OSMOLAR SOLUTIONS WITH HIBI - TANE ON SHED CANCER CELLS IN PERITONEAL CAVITY OF PATIENTS WITH GASTRIC CANCER

For 100 patients with gastric canvw, intraopemtive intraperitoneal perfusion (IOIPP) using double - distilled water(D. D. W) with hibitane 37°C for 5 mlmge$ was performed. The anticancer effects were assessed cytologically in pre- IOIPP and post-IOIPP specimens of the abdominal effusion and/or iavaged peritoneal fluid. The radical gastrectomy was performed in 65 of 93 cases with advanced gastric cancer, shed cancer cells in peritoneal cavity were detected in 16 of 65 cases with pre- IOIPP (24.62%) and in3 of post- IOIPP cases (4.62%). There was siguificant difftTmce between the two groups (P<0.01). Shed cancer cells were inactivated in vivo estimated by the trypan- blue staining tedmique in 7 cases with rmiicui surgery. But the effect of the IOIPP on shed cancer cells was not significant in cases with peritoneal metastasis. Also there were shed cancer cells in peritoneal cavity of patients with SS cancer histologically before the IOIPP (15.56% ) and iatrogeuic diffmion of cancer cells dm-ing operation (7/24) in this article. The above results indicated that the IOIPP with hypo - osmolar solution containing, hibitane, 37°C for 5 rain was indispensable and useful for the killing of peritoneal shed cancer cells in order to prevent postoperative peritoneal recurrence in patients with radical surgery of advanced gastric cancer regardless of conditiom of serosal invasion.