Original Articles


THE EARLY RELATIVE BIOLOGICAL EFFECTIVENESS OF SINGLE DOSE OF FAST NEUTRONS (35 MeVp→Be) FOR BONE MARROW IN MICE

Yan Sun, Shukui Han, Bo Xu, Shuhui Zhang, Jinghua Tang, Weike Chang, Wenjiang Shen

Abstract

The early RBE of the bone marrow in mice after single irradiation with fast neutrons (35 MeVp→Be ) was studied. 60Co-γ ray was used for referent beams. Using the dose making 50% loss of the nucleated cells of bone marrow in mice relative to control group mice to calculated the RBE value which was 2.13±0.18. Meanwhile, the relationship of the RBE values and the dose of neutrons was noted. On log-log plot, the RBE values decrease with increasing dose of fast neutrons and it is consistent with a slope of -0.39± 0.10. The α/β ratios were estimated from linear-quadratic model of cell survival, they are 14.4±1.30 Gy for fast neutrons and 0.83±0.10 Gy for γ-ray, respectively.