Basic Investigations

INTERACTION OF CISPLATIN WITH MEMBRANES OF RAT EHRLICH ASCITES TUMOR CELL*

Baowei Chen, Kui Wang

Abstract

Quenching effects of cis-DDP on fluorescence of membranes of rat Ehrlich ascites tumor cell and binding of cis-DDP with the membranes were studied. The results indicate that cis-DDP can react with tumor cell membrane proteins. If the Pt binding sites were grouped into two types, the apparent stability canstants (K) and number of binding sites (n) are estimated.