Original Articles
A PRIMARY STUDY OF THE CORRELASTIONS BETWEEN HUMAN LEUKOCYTE ANTIGEN (HLA) AND OSTEOSARCOMA
Abstract
Objective: To study the correlations between human leukocyte antigen (HLA) and osteosareoma in Chinese Han nationality.
Methods: The frequencies of HLA-A, B, DR, DQ locus antigens were tested in a group of 25 osteosareoma patients in comparison with 250 healthy controls by using complement-dependent microlymphocytotoxity technique. Both of them are Chinese Han nationality. The results were compared statistically.
Results: The frequency of HLA-B35 was 0.400 in patient group, and comparing with 0.048 in controls. The relative risk of suffering from osteosareoma in persons carrying HLA-B35 was 13.220 times as high as that in those without this antigen (P<0.01). Patients with HLA-B13 had increased in the relative risk of poor prognosis with 12.048 fold comparing with those without this antigen (P<0.05). A tendency of the worst prognosis was presented in the patients who carry both HLA-B13 and HLA.B35. For those patients with HLA.B40, the relative safety was 7.057 times higher than the negative persons (P<0.05).
Conclusion: HLA-B35 is in close linkage to osteosarcoma susceptibility genes in Chinese Han nationality. HLA-B13 and HLA-B40 may be associated to the malignant and resistant genes of osteosarcoma respectively.
Methods: The frequencies of HLA-A, B, DR, DQ locus antigens were tested in a group of 25 osteosareoma patients in comparison with 250 healthy controls by using complement-dependent microlymphocytotoxity technique. Both of them are Chinese Han nationality. The results were compared statistically.
Results: The frequency of HLA-B35 was 0.400 in patient group, and comparing with 0.048 in controls. The relative risk of suffering from osteosareoma in persons carrying HLA-B35 was 13.220 times as high as that in those without this antigen (P<0.01). Patients with HLA-B13 had increased in the relative risk of poor prognosis with 12.048 fold comparing with those without this antigen (P<0.05). A tendency of the worst prognosis was presented in the patients who carry both HLA-B13 and HLA.B35. For those patients with HLA.B40, the relative safety was 7.057 times higher than the negative persons (P<0.05).
Conclusion: HLA-B35 is in close linkage to osteosarcoma susceptibility genes in Chinese Han nationality. HLA-B13 and HLA-B40 may be associated to the malignant and resistant genes of osteosarcoma respectively.
