Original Articles
NK ACTIVITY OF LYMPHOCYTE SUBSETS AND THE EFFECTS OF LOW DOSE RADIATION
Abstract
Objective: To determine the NK activity of lymphocyte subsets and the effects of low dose radiation.
Methods: Lymphocyte subsets were separated by monoclonal antibodies. The NK activity of each subset on tumor cells was detected by radioactive release method.
Results: The results showed that besides NK cells, CD4, CDa and B cells alone can kill tumor cells. But the cellkilling activity of NK cells appeared to be strongest. There was synergistic effect between CD4 and NK cells. The activity of mixed lymphocytes was more than that of only one subset. The effect of low dose radiation (LDR) on NK activity of paulymphocytes or NK cells was different.
Conclusion: This paper demonstrated that NK activity of mononuclear cells was called "NK activity of iymphocytes", but it is not true. Only when NK cells were separated by monocional antibodies, its killer activity can be called "activity of NK cells".
Methods: Lymphocyte subsets were separated by monoclonal antibodies. The NK activity of each subset on tumor cells was detected by radioactive release method.
Results: The results showed that besides NK cells, CD4, CDa and B cells alone can kill tumor cells. But the cellkilling activity of NK cells appeared to be strongest. There was synergistic effect between CD4 and NK cells. The activity of mixed lymphocytes was more than that of only one subset. The effect of low dose radiation (LDR) on NK activity of paulymphocytes or NK cells was different.
Conclusion: This paper demonstrated that NK activity of mononuclear cells was called "NK activity of iymphocytes", but it is not true. Only when NK cells were separated by monocional antibodies, its killer activity can be called "activity of NK cells".
