Original Articles
APOPTOTIC THRESHOLD OF ADRIAMYCIN AND CISPLATIN IN HEPATOCELLULAR CARCINOMA
Abstract
Objective: To investigate the apoptotie threshold of adriamycln (ADM) and cisplatin (CDDP) on hepatocellular carcinoma (HCC).
Methods: Sensitivities of ADM and CDDP on HCC were studied by primary cell culture.
Results: The apoptotie threshold of ADM and CDDP were 1.0μg/ml and 1.5μg/ml respectively (its clinical dosage was 20 rng and 30 mg respectively).
Conclusion: Understanding apoptotic threshold of anticancer drugs may reduce elinieal dosages of anticaneer drugs and reduce the incidence of multidrug resistance (MDR).
Methods: Sensitivities of ADM and CDDP on HCC were studied by primary cell culture.
Results: The apoptotie threshold of ADM and CDDP were 1.0μg/ml and 1.5μg/ml respectively (its clinical dosage was 20 rng and 30 mg respectively).
Conclusion: Understanding apoptotic threshold of anticancer drugs may reduce elinieal dosages of anticaneer drugs and reduce the incidence of multidrug resistance (MDR).
