Original Articles
EXPRESSION OF BASIC FIBROBLAST GROWTH FACTOR, TRANSFORMING GROWTH FACTOR 1~1 AND THEIR RECEPTORS IN OSTEOSARCOMA AND ITS RELATIONSHIP TO ANGIOGENESIS
Abstract
Objective: To investigate the expression of angiogenir factors, basic fibroblast growth factor (bFGF) and transforming growth factor (TGF)-β1 in osteosareoma, its association with neovascnlarization and prognosis.
Methods: The expression of bFGF, TGF-β1 and their receptors, as well as intratumoral microvessel count (MVD) were studied in 80 osteosarcomas by immunohistochemical staining and morphnmetry. The relationship between the angiogenie factors expression and prognosis was evaluated by a multivariate analysis using Cox proportion hazard model.
Results: Among 80 cases of osteosareoma, 46 cases were positive for bFGF/bFGFr (57.5%), and 31 cases for TGF-β1/ TGF-β(RI)(38.8%) respectively. The MVD and bFGF, TGF-β1 were important indicators to predict the prognosis of patients with osteosareoma by the Cox proportion hazard model analysis.
Conclusion: The angiogenic factors bFGF and TGF-β1 are involved in the anglogenesis of osteosaremna, and the angiogenesis influences the prognosis. Also they may be useful in the evaluation of the prognosis of patients with osteosarcoma.
Methods: The expression of bFGF, TGF-β1 and their receptors, as well as intratumoral microvessel count (MVD) were studied in 80 osteosarcomas by immunohistochemical staining and morphnmetry. The relationship between the angiogenie factors expression and prognosis was evaluated by a multivariate analysis using Cox proportion hazard model.
Results: Among 80 cases of osteosareoma, 46 cases were positive for bFGF/bFGFr (57.5%), and 31 cases for TGF-β1/ TGF-β(RI)(38.8%) respectively. The MVD and bFGF, TGF-β1 were important indicators to predict the prognosis of patients with osteosareoma by the Cox proportion hazard model analysis.
Conclusion: The angiogenic factors bFGF and TGF-β1 are involved in the anglogenesis of osteosaremna, and the angiogenesis influences the prognosis. Also they may be useful in the evaluation of the prognosis of patients with osteosarcoma.
