Original Articles
HISTOLOGICAL GRADING IN DUCTAL CARCINOMA IN SITU OF THE BREAST
Abstract
Objective: To study the significance of histological grading as a prognostic factor in ductal carcinoma in situ of the breast.
Methods: According to the Van Nuy's classification, 32 cases of ductal carcinoma in silu (DCIS) of the breast were divided into three groups.
Results: Low grade (well differentiated, low grade DCIS) 12 patients (37.5%); Intermediate grade, 9 patients (28.1%); High grade (poorly differentiated DCIS) 11 patients (34.4%). Among the high grade DCIS, the histologic subtypes were comedo (9 patients), micropapillary (1 patient) and solid (1 patient). The positive expression of c.erbB-2, p53 and MIB- 1 in high grade DCIS was higher than that in intermediate and low grade DCIS. The difference between high grade and low grade DCIS was significant (P<0.05). The expression of ER in high grade DCIS was lower than that in intermediate and low grade DCIS.
Conclusions: Histological grading of breast ductal carcinoma in situ may be a good prognostic factor.
Methods: According to the Van Nuy's classification, 32 cases of ductal carcinoma in silu (DCIS) of the breast were divided into three groups.
Results: Low grade (well differentiated, low grade DCIS) 12 patients (37.5%); Intermediate grade, 9 patients (28.1%); High grade (poorly differentiated DCIS) 11 patients (34.4%). Among the high grade DCIS, the histologic subtypes were comedo (9 patients), micropapillary (1 patient) and solid (1 patient). The positive expression of c.erbB-2, p53 and MIB- 1 in high grade DCIS was higher than that in intermediate and low grade DCIS. The difference between high grade and low grade DCIS was significant (P<0.05). The expression of ER in high grade DCIS was lower than that in intermediate and low grade DCIS.
Conclusions: Histological grading of breast ductal carcinoma in situ may be a good prognostic factor.
