@article{CJCR987,
author = {Yu Li and Xiu-Feng Ye and Guo Qian and Yu Yin and Qian-Guan Pan},
title = {Pathologic features and clinical outcome of central neurocytoma: analysis of 15 cases},
journal = {Chinese Journal of Cancer Research},
volume = {24},
number = {4},
year = {2012},
keywords = {},
abstract = {Objective: In order to get better recognition of central neurocytoma and diminish misdiagnose.
Methods: A retrospective review identified 15 cases of central neurocytoma. All cases of central neurocytoma were analyzed for their clinical symptoms, pathologic changes, immunohistochemical staining, prognosis and differential diagnosis. Clinical follow-up was available for 11 patients.
Results: There were 8 males and 7 females whose ages ranged from 10 to 64 years (median 32.93 years). The most common presenting symptoms were those related to increased intracranial pressure (ICP), including headache (100%), papilledema (93%) and vomiting (80%). All tumors were located in the ventricular system. The tumors were composed of uniform cells with round nuclei and a fine chromatin pattern and in some areas small cells with perinuclear halo could be seen. In particular, the anuclear areas may have a fine fibrillary matrix (neuropil). Nuclear atypia and vascular proliferation appeared in two cases, respectively. Focal necrosis could be seen in one case. Immunohistochemical findings included expression of synaptophysin [15/15], neuron specific enolase [12/15] and glial fibrillary acidic protein [3/15]. While MIB-1 proliferation index ranged from 0.8-12.5%, and were more than 2% in 3 of 15 cases assessed. Follow-up information was available for eleven patients.
Conclusions: Central neurocytomas have a favorable prognosis in general, but in some cases the clinical course could be aggressive. Increase of GFAP positivity, proliferation index and vascular proliferation might suggest a more malignant process.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/987}
}