@article{CJCR940,
author = {Li-qun Yu and Guo-lan Gao and Fun-jun Liu and Qiong-jing Zeng},
title = {Dys-psychological Stress Effect on Expressions of P53 and NFκBp65 in Human Ovarian Carcinoma In Vivo},
journal = {Chinese Journal of Cancer Research},
volume = {24},
number = {3},
year = {2012},
keywords = {},
abstract = {Objective: To investigate the dys-psychological stress effect on the growth of subcutaneous xenotransplanted tumor in nude mice bearing human epithelium ovarian carcinoma, and the influence on P53 and NFκBp65 expressions.
Methods: The subcutaneous tumor xenografts were established by implanting human epithelium ovarian carcinoma tissues into nude mice and the dys-psychological stress model was established with restraint. The mice were randomized into the following four treatment groups with each group six mice respectively: tumor group (group A), normal saline intraperitoneal injection; tumor with stress group (group B), normal saline intraperitoneal injection; tumor therapy group (group C), cisplatin intraperitoneal injection; and tumor therapy with stress group (group D), cisplatin intraperitoneal injection. The expressions of P53 and NFκBp65 in tumor tissues were determined by Western blotting.
Results: The expressions of P53 and NFκBp65 in each restraint group were enhanced compared with the control groups (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/940}
}