@article{CJCR876,
author = {Ping-ping Wu and Ji-hong Zou and Ri-ning Tang and Yao Yao and Cheng-zhong You},
title = {Detection and Clinical Significance of DLC1 Gene Methylation in Serum DNA from Colorectal Cancer Patients},
journal = {Chinese Journal of Cancer Research},
volume = {23},
number = {4},
year = {2012},
keywords = {},
abstract = {Objective: Deleted in liver cancer 1 (DLC1) is a new candidate tumor suppressor gene, whose down‐regulation or even silence will result from promoter hypermethylation in various human cancers including colorectal cancer (CRC). The aim of this study is to evaluate the diagnostic role of DLC1 gene methylation in the serum DNA from CRC patients. Methods: This study enrolled 85 CRC patients and 45 patients with benign colorectal diseases. Methylation‐specific polymerase chain reaction (MSP) was used to determine the promoter methylation status of DLC1 gene in serum DNA. The combination of DLC1 methylation and conventional tumor markers was further analyzed. Results: Hypermethylation of DLC1 was detected in 42.4% (36/85) of CRC serums, while seldom in the benign controls (8.9%, 4/45) (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/876}
}