@article{CJCR867,
author = {En-Yi Liu and Mei-Zuo Zhong and Cai-Gang Liu and Jin Huang and Wei Liu and Shan Zeng and Bin Li and Jing-Chen Lu and Jian-Huang Li and Hai-Rong Jiang},
title = {Recurrent Patterns and Factors Involved in Node-negative Advanced Gastric Cancer},
journal = {Chinese Journal of Cancer Research},
volume = {22},
number = {4},
year = {2012},
keywords = {},
abstract = {Objective: To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection.
Patients and Methods: Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and received curative resection between 2002 and 2006 were retrospectively evaluated.
Results: Among the 300 patients, 15 (5.0%) had locoregional recurrence, 5 (1.7%) had lymph node recurrence, 27 (9.0%) had peritoneal seeding recurrence, and 21 (7.0%) had hematogenous metastasis. Using multivariate analysis, we found that the maximum tumor diameter (P=0.014), histological type (P=0.001) and Borrmann type (P=0.033) were independent factors predicting the locoregional recurrence. Lymph node recurrence was significantly affected by lymph node dissection (P=0.029) and lymphovascular invasion (P=0.004). Clinicopathological factors predicting the peritoneal seeding recurrence were the depth of invasion (P=0.001) and Borrmann type (P=0.002). In addition, lymphovascular invasion (P=0.013) and histological type (P=0.001) were significantly associated with hematogenous metastasis.
Conclusion: Node-negative advanced gastric cancer has a high amount of peritoneal seeding and hematogenous metastasis.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/867}
}