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Overexpression and Immunosuppressive Functions of Transforming Growth Factor 1, Vascular Endothelial Growth Factor and Interleukin-10 in Epithelial Ovarian Cancer

   
@article{CJCR844,
	author = {Chan-zhen Liu and Li Zhang and Xiao-hong Chang and Ye-xia Cheng and Hong-yan Cheng and Xue Ye and Tian-yun Fu and Jun Chen and Heng Cui},
	title = {Overexpression and Immunosuppressive Functions of Transforming Growth Factor 1, Vascular Endothelial Growth Factor and Interleukin-10 in Epithelial Ovarian Cancer},
	journal = {Chinese Journal of Cancer Research},
	volume = {24},
	number = {2},
	year = {2012},
	keywords = {},
	abstract = {Objective: Transforming growth factor-1 (TGF-Β1), vascular endothelial growth factor (VEGF), and interleukin-10 (IL-10) may be critical cytokines in the microenvironment of a tumor, playing roles in immune suppression. This study was conducted to elucidate the roles and immunosuppressive functions of these cytokines in epithelial ovarian cancer (EOC). Methods: The expression levels of TGF-Β1, VEGF and IL-10 in malignant tissue were evaluated by immunehistochemistry and compared with corresponding borderline, benign, and tumor-free tissues. Moreover, relationships among the levels of these cytokines and correlations between expression and the prognosis of EOC were analyzed by Pearson rank correlations and multi-factor Logistic regression. The roles of TGF-Β1, VEGF, and IL-10 in the immunosuppressive microenvironment of ovarian cancer were studied through dendritic cell (DC) maturation and CD4+CD25+FoxP3+ Treg generation in vitro experiments. Results: TGF-Β1, VEGF, and IL-10 were expressed in 100%, 74.69%, and 54.96% of EOC patients, respectively. TGF-1 was an independent prognostic factor for EOC. IL-10 was significantly co-expressed with VEGF. In vitro, VEGF and TGF-Β1 strongly interfered with DC maturation and consequently led to immature DCs, which secreted high levels of IL-10 that accumulated around the tumor site. TGF-Β1 and IL-10 induced Treg generation without antigen presentation in DCs. Conclusions: TGF-Β1, VEGF and IL-10 play important roles in EOC and can lead to frequent immune evasion events.},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/844}
}