How to cite item

Expressions of Osteopontin (OPN), ανβ3 and Pim-1 Associated with Poor Prognosis in Non-small Cell Lung Cancer (NSCLC)

   
@article{CJCR839,
	author = {Yi Jin and Da-yue Tong and Lu-ying Tang and Jian-ning Chen and Jing Zhou and Zhi-ying Feng and Chun-kui Shao},
	title = {Expressions of Osteopontin (OPN), ανβ3 and Pim-1 Associated with Poor Prognosis in Non-small Cell Lung Cancer (NSCLC)},
	journal = {Chinese Journal of Cancer Research},
	volume = {24},
	number = {2},
	year = {2012},
	keywords = {},
	abstract = {objective: To examine the expressions of osteopontin (OPN), ανβ3 and Pim-1 in non-small cell lung cancer (NSCLC), and investigate their potential pathogenic roles in the development of NSCLC. Methods: Immunohistochemistry was used to examine the expressions of OPN, ανβ3 and Pim-1 in cohort (136 cases) of NSCLC samples and their adjacent normal lung tissue specimens. Statistical analysis was performed to evaluate the relationships among expressions of OPN, ανβ3 and Pim-1 and their associations with patients clinicopathological parameters. Results: The expressions of OPN and Pim-1 were predominantly observed in cytoplasm. The expression of ανβ3 was mostly detected in cytoplasm and/or membrane. In NSCLC samples, the positive rates of OPN, ανβ3 and Pim-1 expressions were 68.4% (93/136), 77.2% (105/136) and 57.4% (78/136), respectively. In normal lung tissues, in contrast, the positive rates of OPN, α  β3 and Pim-1 were 24.0% (12/50), 26.0% (13/50) and 16.0% (8/50), respectively. There were significant differences of the positive expression rates of OPN, ανβ3 and Pim-1 between NSCLCs samples and normal lung tissues (P},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/839}
}