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Synergistic Action of fMLP-boanmycin Combination on the Growth of Mouse Colon Carcinoma and Its Action Mechanisms

   
@article{CJCR826,
	author = {Zhong-dong Li and Yan Gao},
	title = {Synergistic Action of fMLP-boanmycin Combination on the Growth of Mouse Colon Carcinoma and Its Action Mechanisms},
	journal = {Chinese Journal of Cancer Research},
	volume = {22},
	number = {2},
	year = {2012},
	keywords = {},
	abstract = {Objective: The inhibitory action of fMLP-boanmycin (BAM) combination on the growth of mouse colon carcinoma and its action mechanisms were observed in order to provide experimental proof for probing novel regimen of chemotactic modulation in combination with chemotherapy in the treatment of cancer. 
Methods: Cytotoxicity of BAM-fMLP combination to tumor cells was determined by MTT assay in vitro. Antitumor activity of BAM-fMLP combination was assessed in mice subcutaneously transplanted colon carcinoma 26. The amount of superoxide anion (O2‧) released from fMLP stimulated macrophages was determined by NBT assay. The amount of nitric oxide (NO) was indirectly determined by Griess method. 
Results:BAM-fMLP combination had no synergistic effect on tumor cells(CDI>0.85), but BAM at the doses of 10μg/ml, 30μg/ml and 100μg/ml in combination with fMLP at the concentration 20μg / ml exhibited synergistic effect on tumor cells in the presence of macrophages(CDI},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/826}
}