@article{CJCR820,
author = {Ke-min Jin and Min Lu and Fang-fang Liu and Jin Gu and Xiao-juan Du and Bao-cai Xing},
title = {Cortactin Overexpression Correlates with Poor Prognosis in Hepatocellular Carcinoma},
journal = {Chinese Journal of Cancer Research},
volume = {22},
number = {2},
year = {2012},
keywords = {},
abstract = {Objective: To investigate cortactin expression in hepatocellular carcinoma (HCC) and explore its significance in the prognosis of HCC patients.
Methods: Immunohistochemistry was performed for paraffin samples of 119 pairs of HCC tissues (HCCs) and paratumorous liver tissues (PTLTs) to evaluate cortactin expression. The cortactin expression difference in HCCs and PTLTs were analyzed by the McNemar’s test. The relationship of cortactin expressions in HCCs and clinicopathologic factors was analyzed with Mann-Whitney U test. The Kaplan-Meier method and log-rank test were employed to compare the overall survival between Cortactin negative expression group, weak expression group and strong expression group. Expression of cortactin was further determined in 19 pairs of fresh HCCs and PTLTs specimens with Western blotting.
Results: Cortactin expression rate was significantly higher in HCCs (53/119, 44.5%) than that in PTLTs (2/119, 1.7%) (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/820}
}