@article{CJCR819,
author = {Chun-gen Xing and Xue-guan Lu and Yong-sheng Zhang and Fang Zhou and Xiao-ping Xu},
title = {Expression of Embryonic Stem Cell Marker Oct-4 and Its Prognostic Significance in Rectal Adenocarcinoma},
journal = {Chinese Journal of Cancer Research},
volume = {22},
number = {2},
year = {2012},
keywords = {},
abstract = {Objective: Recent evidence suggests that Oct-4 is highly expressed in several cancers, and its expression contributes to tumor growth. In this study, we investigated the level of Oct-4 expression in rectal adenocarcinoma, and evaluated the prognostic significance of Oct-4 expression in these cases.
Methods: The immunohistochemical expression of Oct-4 was evaluated in 52 formalin-fixed paraffin-embedded postoperative rectal adenocarcinoma tissue samples. The impact of the immunoreactivity of Oct-4 in regard to clinical outcome was determined by Kaplan-Meier and log-rank.
Results: The expression level of Oct-4 ranged from 0 to 18.5%. There was no significant association between Oct-4 expression and gender (P=0.772), age (P=0.123), clinical stage (P=0.391), and histological grade (P=0.056). The 3-year local recurrence-free rates with negative and positive expression of Oct-4 were 83.5% and 75.0%, respectively (P=0.583). The 3-year metastasis-free rates with negative and positive expression of Oct-4 were 88.6% and 61.9%, respectively (P=0.035). The 3-year overall survival rates with negative and positive expression of Oct-4 were 77.9% and 49.0%, respectively (P=0.037).
Conclusion: The results suggest that embryonic stem cell marker Oct-4 expression may have prognostic significance in patients with rectal adenocarcinoma. However, to confirm this more and larger studies are required.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/819}
}