@article{CJCR7243,
author = {Nedim Turan and Mustafa Benekli and Olcun Umit Unal and İlkay Tugba Unek and Didem Tastekin and Faysal Dane and Efnan Algın and Sukran Ulger and Tulay Eren and Turkan Ozturk Topcu and Esma Turkmen and Nalan Akgül Babacan and Gulnihal Tufan and Zuhat Urakci and Basak Oven Ustaalioglu and Ozlem Sonmez Uysal and Ozlem Balvan Ercelep and Burcu Yapar Taskoylu and Asude Aksoy and Mustafa Canhoroz and Umut Demirci and Erkan Dogan and Veli Berk and Ozan Balakan and Ahmet Şiyar Ekinci and Mukremin Uysal and İbrahim Petekkaya and Selçuk Cemil Ozturk and Önder Tonyalı and Bülent Çetin and Mehmet Naci Aldemir and Kaan Helvacı and Nuriye Ozdemir and İlhan Oztop and Ugur Coskun and Aytug Uner and Ahmet Ozet and Suleyman Buyukberber and Anatolian Society of Medical Oncology (ASMO)},
title = {Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma},
journal = {Chinese Journal of Cancer Research},
volume = {27},
number = {4},
year = {2015},
keywords = {},
abstract = {Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC).
Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013.
Results: Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered.
Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/7243}
}