@article{CJCR4376,
author = {Xin Liu and Ming-Zhu Huang and Zhi-Yu Chen and Xiao-Yin Zhao and Chen-Chen Wang and Wei Peng and Ji-Liang Yin and Jin Li and Xiao-Dong Zhu},
title = {LRP5 polymorphism—A potential predictor of the clinical outcome in advanced gastric cancer patients treated with EOF regimen},
journal = {Chinese Journal of Cancer Research},
volume = {26},
number = {4},
year = {2014},
keywords = {},
abstract = {Purpose: Wnt pathways control key biological processes that potentially impact on tumor progression and patient survival. The present study analyzed the polymorphism of lipoprotein-related receptor 5 (LRP5M) (gene with key functions in Wnt signaling) and its impact on the response to chemotherapy and survival of patients with advanced gastric cancer (AGC).
Methods: A total of 107 consecutive patients with AGC treated with first-line chemotherapy of EOF regimen were enrolled in the present retrospective study. The association between single nucleotide polymorphism (SNP) of rs3736228 in LRP5M and the clinical outcomes of the patients was studied.
Results: The CC genotype of rs3736228 was significantly correlated with a higher disease control rate when compared to the CT and TT genotypes (89.3% and 61.8%, respectively, P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/4376}
}