TY  - JOUR
AU  - Chen, Lian
AU  - Chen, Rui
AU  - Zhu, Zhe
AU  - Zhang, Yichen
AU  - Wen, Zhengwei
AU  - Li, Yun
AU  - Li, Xiaoming
AU  - Luo, Yuwen
AU  - Ma, Liyu
AU  - Lin, Shuguang
AU  - Chen, Xin
PY  - 2014
TI  - Predictive factors associated with gefitinib response in patients with advanced non-small-cell lung cancer (NSCLC)
JF  - Chinese Journal of Cancer Research; Vol 26, No 4 (August 20, 2014): Chinese Journal of Cancer Research
Y2  - 2014
KW  - 
N2  - Purpose: A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in advanced non-small-cell lung cancer (NSCLC). This study aimed to identify predictive factors associated with prognostic benefits of gefitinib.   Patients and methods: EGFR gene typing in 33 advanced NSCLC patients received gefitinib (250 mg/day) were analyzed with mutant-enriched PCR assay. Gefitinib response was evaluated with potential predictive factors retrospectively.   Results: The overall objective response rate (ORR) and median progression-free survival (PFS) in the 33 patients treated by gefitinib were 45.5% and 3.0 (2.0-4.0) months. The ORR and median PFS in EGFR gene mutation patients were significantly higher/longer than those in EGFR gene wild-type patients (P<0.01). Similarly, the ORR and median PFS in non-smoker patients were significantly higher/longer than those in smoker patients (P<0.05, P<0.01, respectively). However, no difference for ORR and median PFS occurred between male and female patients. Logistic multivariate analysis showed that only EGFR mutated gene was significantly associated with the ORR (P<0.01). Both EGFR mutated gene and non-smoker were the major factors that contributed to PFS (P<0.05).   Conclusions: EGFR mutated gene and non-smoker status are potential predictors for gefitinib response in NSCLC patients.
UR  - https://cjcr.amegroups.org/article/view/4351