@article{CJCR3694,
author = {Bo Zeng and Yiyan Lei and Haoshuai Zhu and Shenyuan Luo and Mei Zhuang and Chunhua Su and Jianyong Zou and Lei Yang and Honghe Luo},
title = {Aurora-A is a novel predictor of poor prognosis in patients with resected lung adenocarcinoma},
journal = {Chinese Journal of Cancer Research},
volume = {26},
number = {2},
year = {2014},
keywords = {},
abstract = {Background: The Aurora-A (Aur-A) gene, a key regulator of mitosis, has been proved as an oncogene in a variety of cancers. The Aur-A overexpression has been proved correlated with aggressiveness of cancer cells. However, the frequency of Aur-A protein overexpression, as well as its association with clinicopathologic parameters and prognosis remain unclear in lung adenocarcinoma (ADC). This study tried to clarify the clinical significance of Aur-A in patients with resected lung ADC.
Patients and methods: A total of 142 informative patients with surgically resected lung ADC and 20 normal lung tissues were enrolled. Western blot and immunohistochemistry (IHC) were utilized to assess protein expression of Aur-A.
Result: The expression of Aur-A was elevated in most of tumor tissues compared with the adjacent tissues by western blot. The IHC results showed that Aur-A protein was over-expressed in 98 of 142 (69.0%) tumor sections, while Aur-A was low-expressed in all normal lung sections. A positive correlation between Aur-A overexpression rate and ascending pathologic stages was observed (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/3694}
}