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PARP inhibitor reduces proliferation and increases apoptosis in breast cancer cells

   
@article{CJCR3691,
	author = {Yan Shi and Fang Zhou and Feng Jiang and Hong Lu and Jianjun Wang and Chuanyao Cheng},
	title = {PARP inhibitor reduces proliferation and increases apoptosis in breast cancer cells},
	journal = {Chinese Journal of Cancer Research},
	volume = {26},
	number = {2},
	year = {2014},
	keywords = {},
	abstract = {Objective: Apoptosis is a reliable marker of chemotherapeutic efficacy. Olaparib and paclitaxel inhibit proliferation and induce apoptosis in a variety of cancers. We investigated the effects of paclitaxel combined with olaparib on apoptosis in breast cancer Bcap37 cells.
Methods: Proliferation and apoptosis were detected by MTT assay and PI staining. Degradation of pro-caspase-3 and poly(ADP-ribose) polymerase (PARP) was analyzed by Western blotting.
Results: Compared with paclitaxel alone, paclitaxel combined with 100 mg olaparib significantly reduced survival in Bcap37 cells at all tested treatment durations (P},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/3691}
}