@article{CJCR3347,
author = {Hui Yu and Xiuying Huang and Zhihua Zhu and Yi Hu and Wei Ou and Lanjun Zhang and Ningning Zhou},
title = {Significance of combined detection of LunX mRNA and tumor markers in diagnosis of lung carcinoma},
journal = {Chinese Journal of Cancer Research},
volume = {26},
number = {1},
year = {2014},
keywords = {},
abstract = {Objective: To evaluate the significance of combined detection of LunX mRNA, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and cytokeratin 21-1 fragment (CYFRA21-1) in clinical diagnosis of lung carcinoma.
Methods: Based on the quantitative RT-PCR and chemiluminescence immunoassay, the expression levels of LunX mRNA, CEA, NSE, and CYFRA21-1 in 113 patients with lung carcinoma (case group) and 30 healthy participants (control group) were detected. Meantime, the sensitivity, specificity, and accuracy of the combination detection were also explored.
Results: The positive rates of LunX mRNA in peripheral blood and CEA, NSE, and CYFRA21-1 in serum were significantly higher in case group than those in control group (χ2=17.295, 16.825, 19.148, and 17.450; P0.05). The positive rate of LunX mRNA in stage I + II, III, and IV had a significantly increasing tendency (χ2=10.565, 32.462, P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/3347}
}