@article{CJCR2484,
author = {Chunyan Lin and Xudong Dai and Xiwen Sun and Fenghua Li and Yubo Shi},
title = {EXPRESSION OF P53 AND C-MYC IN MOUSE LUNG CANCER INDUCED BY COAL BURNING},
journal = {Chinese Journal of Cancer Research},
volume = {8},
number = {4},
year = {2013},
keywords = {},
abstract = {Previous epidemiological studies have shown association between coal burning and human lung cancer. To confirm relationship between coal burning and lung cancer formation and progression the expression of p53 and c-myc in 13 mouse lung cancer induced by coal burning smoke and 5 mouse lung tissue control was studied by DNA-RNA in situ hybridization (ISH). Nine of 13 specimens showed c-myc overexpression but it occurred only 1 of adjacent tissue. There was over pression of p53 mRNA in all 13 lung cancer and 5 adjacent tissue. None in the controls was expression of p53 and c-myc detected. When compared to controls, there was significant higher expression of c-myc gene (P=0.002) and p53 geuc (P=0.0001).
The results confirm that overexpression of p53 and c-myc are common molecular events of lung cancer by coal burning smoke and provide further evidence that smoke from coal burning is a causative agent of lung cancer.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/2484}
}