@article{CJCR2346,
author = {Yanong Wang and Daren Shi and Zhenzhou Shen and Renyuan Zhang and Shouye Liu},
title = {INVESTIGATION OF RELATIONSHIPS BETWEEN KI-67 SCORE, DNA INDEX, AND HISTOLOGIC GRADE IN SOFT TISSUE SARCOMAS},
journal = {Chinese Journal of Cancer Research},
volume = {8},
number = {1},
year = {2013},
keywords = {},
abstract = {Proliferative activity of soft tissue sarcomas (STS) in 31 cases was estimated by histologic grading, mitotic count, DNA analysis by flow cytometry, and immunohistochemical procedures with monoclonal antibody Ki-67. Aneuploid was found in 12 of 16 cases (75.0%) with Grade 3, and in 4 of 15 cases (26.7%)with Grade 1, 2 (P=0.0121). Tumors with more than 100 Ki-67 positive tumor cells per 10 high power fields (HPF) had a higher rate of aneuploid (81.3%) than those with less than 100 Ki-67 per 10 HPF (26.7%) (P=0.0038). There were significant correlations between Grade and DI (r=0.4901, P=-0.0051), Grade and Ki-67 (r=0.4636, P=0.0086), Ki-67 and DI (r=0.6368, P=-0.0001). The results indicate that DI and reactivity of tumor cells to Ki-67 may reflect proliferative activity and be helpful for clinicians to judge the biological behaviour of tumors more accurately and objectively. Supplementary to the grading of STS, DI and Ki-67 score could be useful as prognostic parameters for clinical investigation of muitimodality therapy for individual patients.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/2346}
}