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THE EFFECTOR FUNCTIONS OF MACROPHAGES TRANSFECTED WITH INTERFERON- GAMMA GENE MEDIATED BY RECOMBINANT ADENOVIRUS1

   
@article{CJCR2312,
	author = {Hong Lei and Xuetao Cao and Yizhi Yu and Guoyou Chen and Minghui Zhang},
	title = {THE EFFECTOR FUNCTIONS OF MACROPHAGES TRANSFECTED WITH INTERFERON- GAMMA GENE MEDIATED BY RECOMBINANT ADENOVIRUS1},
	journal = {Chinese Journal of Cancer Research},
	volume = {9},
	number = {4},
	year = {2013},
	keywords = {},
	abstract = {Macrophages(M∅s) are not only a kind of immune effector cells but also a kind of antigen-presenting cells(APC). In order to improve their antitumor effect, we transfected interferon-gamma(IFN-γ) gene into M∅s by recombinant adenovirus because IFN-γ is a kind of potent macrophage-activating factor(MAF). High level of IFN-γ could be detected in the supernatants of Mq∅s after IFN-γ gene transfection and IFN-γ secretion peaked at 20 hour. The cytotoxicity of IFN-γ genetransfected M∅s increased significantly. The secretion of TNF, IL-1, nitric oxide(NO) also increased to some extent. The results demonstrated that recombinant adenovirusmediated IFN-γ gene transfection could improve the effector functions of M∅s efficiently.},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/2312}
}