How to cite item

Ara-C INDUCED APOPTOSIS IN HUMAN MYELOID LEUKEMIA CELL LINE HL-60: INDUCING APOPTOSIS IS THE PRIMARY MECHANISM OF CHEMOTHERAPY

   
@article{CJCR2053,
	author = {Jianfeng Zhou and Yan Chen and Chongyu Li and Jianping Xiang and Dongjiao Yu and Ping Zou and Bianming Wang},
	title = {Ara-C INDUCED APOPTOSIS IN HUMAN MYELOID LEUKEMIA CELL LINE HL-60: INDUCING APOPTOSIS IS THE PRIMARY MECHANISM OF CHEMOTHERAPY},
	journal = {Chinese Journal of Cancer Research},
	volume = {9},
	number = {3},
	year = {2013},
	keywords = {},
	abstract = {Objective: To elucidate the pattern of chemotherapy drugs induced apoptosis and its role in chemotherapy of acute leukemia. 
Methods: Apoptosis induced by Ara-C in human myeloid leukemia cell line HL-60 was investigated by applying light microscope, electron microscopy combined with DNA electrophoresis and flow cytometry analysis techniques. 
Results: Apoptosis persisted throughout 36 h following addition of Ara-C with a gradual augmentation. Efficiency of apoptosis was enhanced in a dosedependent pattern, HL-60 treated with six other chemotherapy drugs and peripheral white blood cells from a AML case undergoing DA regimen chemotherapy exhibited typical DNA ladder pattern. Further investigation indicated that chemotherapy drugs apoptosis came into being possibly by downregulating the expression of c-myc and bcl-2 oncogenes. 
Conclusion: Chemotherapy induced apoptosis is the primary mechanism of chemotherapy.},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/2053}
}