@article{CJCR1929,
author = {Lingfei Xu and Kai Ge and Zhongcheng Zheng and Lanying Sun and Xinyuan Liu},
title = {RETROVIRAL-MEDIATED SUICIDE GENE THERAPY OF EXPERIMENTAL GLIOMA},
journal = {Chinese Journal of Cancer Research},
volume = {10},
number = {3},
year = {2013},
keywords = {},
abstract = {Objective: To establish a retroviral-mediated suicide gene therapy system for experimental glioma and test its efficacy.
Methods: C6 rat glioma cells were infected with recombinant retrovirus containing HSV-tk gene. The C6/tk cell line which stably expressed tk was selected and cloned. The sensitivities of C6/tk cells to several nucleoside analogues, such as GCV, BVdU, ACV were compared by the growth inhibition studies. Antitumor effects were also observed after GCV treatment in nude mice bearing tumors derived from C6/tk cells.
Results: The growth inhibition studies showed that GCV was the most efficient prodrug in this system. C6/tk ceils were highly sensitive to GCV, with an IC50},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1929}
}