@article{CJCR1786,
author = {Ning Xu and Yan-Qing Ding and Li Xu and Hong-ming Qiu},
title = {CLINICOPATHOLOGICAL FEATURES OF RER+ COLORECTAL CARCINOMA},
journal = {Chinese Journal of Cancer Research},
volume = {11},
number = {3},
year = {2013},
keywords = {},
abstract = {Objective: Replication errors (RER) is related to initiation and development of colorectal carcinoma (CRC). To investigate the different biological behavior of RER+ and RER\" CRC.
Methods: Silver staining PCR-single strand conformation polymorphism (PCR-SSCP) and denatured polyacrylamide gel electrophoresis methods were used to detect microsatellite instability (MSI) at 4 loci on chromosome 2, 5, 17 in paraffin-embedded specimens of 60 colorectal carcinoma (CRC) and their paired normal tissue. RER + was scored if 2 or more loci behaved as gaining extra bands.
Results: The results showed that RER § was found in 19/60 CRC, among which 7 cases had a family history. According to the criteria of Amsterdam, 4 were diagnosed as hereditary nonpolyposis colorectal cancer (HNPCC), and of which 3 cases were RER+ The ratio RER+ in HNPCC (75%) was significantly higher than that among sporadic CRC (28.5%). Most of the RER + CRC have the feature of poorly differentiated adenocarcinoma (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1786}
}