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ANALYSIS OF T CELL CLONALITY BY CDR3 SIZE OF T-CELL ANTIGEN RECEPTOR V[3 REPERTOIRE IN HCL AND c-ALL*

   
@article{CJCR1774,
	author = {Yang-qiu Li and Ming-chun Wang and W Siegert and CA Schmadt},
	title = {ANALYSIS OF T CELL CLONALITY BY CDR3 SIZE OF T-CELL ANTIGEN RECEPTOR V[3 REPERTOIRE IN HCL AND c-ALL*},
	journal = {Chinese Journal of Cancer Research},
	volume = {11},
	number = {3},
	year = {2013},
	keywords = {},
	abstract = {Objective: To analyze the distribution and clonality of TCR Vβsubfamily T cells in hairy cell leukemia (HCL) and common-acute lymphoblastic leukemia (c-ALL). 
Methods: Peripheral blood mononuclear cell samples from 3 cases of HCL and 1 case of c-ALL were investigated for analysis of complementarity determining region 3 (CDR3) size of T cell receptor Vβ repertoire using reverse transcriptasepolymerase chain reaction (RT-PCR). The products were further analyzed by genescan to identify T cell clonality. 
Results: Some Vβ subfamily PCR products from 4 patients contained monopeak (monoclone) or a dominant peak (oligoclone). In contrast, multipeak (polyclone) distributions were found in all Vβ subfamily PCR products from normal control cases. 
Conclusion: T cell clonal expansion may be found in HCL and c-ALL cases that may indicate a host response directed against leukemia related antigen. In addition, it may be useful to detect the minimal residual disease.},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/1774}
}