@article{CJCR1654,
author = {Xiaowei Xiao},
title = {RELATIONSHIP BETWEEN PROLIFERATING CELL NUCLEAR ANTIGEN EXPRESSION AND ITS MALIGNANCY POTENTIAL IN COLORECTAL CARCINOMA},
journal = {Chinese Journal of Cancer Research},
volume = {11},
number = {2},
year = {2013},
keywords = {},
abstract = {Objective: To study the relationship between proliferating cell nuclear antigen expression and its malignancy potential in colorectal carcinoma.
Methods: Paraffin sections of 86 patients with advanced coiorectal carcinoma were assessed by immunohistochemical study, using a mouse monoclonal antibody (pc-10, DAKO Co. USA) to check proliferating cell nuclear antigen (PCNA). To compare PCNA with conventional clinicopathologic factor, including p53 overexpression, tissue carcinoembnyonic antigen immunoreactivity pattern and flow cytometric DNA ploidy for assessing tumor malignancy potential. In addition, recurrence and survival of patients with advanced colorectal carcinoma after curative resection were analyzed in accordance with degree of PCNA expression.
Results: PCNAlabeling index (PCNA-LI) increased significantly as the tumor stage advanced (p=0.0001). Strong correlations were observed between PCNA-LI and various pathologic parameters, including histologic differentiation (P=0.0027), lymphatic invasion (P=0.0001), vascular invasion (P=0.0001), lymph node metastasis (P=0.0001), and liver metastasis (P=0.0036). Mean PCNA-LI was also significantly higher in tumor with DNA aneuploidy (P=0.0006) and negative (P=0.01). Linear relationships were demonstrated between PCNALI and clinical outcomes; Recurrence rate was significantly greater in the group with higher than the mean PCNA-LI, who underwent curative resection (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1654}
}