@article{CJCR1647,
author = {Zhongmin Liu and Nanhai Shou and Xihong Jiang},
title = {EXPRESSION OF MDR1, MRP AND LRP GENES IN GASTRIC CARCINOMA AND THEIR CLINICAL SIGNIFICANCE},
journal = {Chinese Journal of Cancer Research},
volume = {11},
number = {2},
year = {2013},
keywords = {},
abstract = {Objective: To explore the expression of mdrl, multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) genes in human gastric cancer and their clinical significance.
Methods: The mdrl mRNA was assayed by RT-PCR, the MRP and LRP were detected by flow cytometry.
Results: The positive rate of mdrl mRNA was 44.4% (12/27), and the mean MRP and LRP expression were independent upon patient histologic type, nodal involvement, and TNM stage. The mdrl mRNA expression in patients with serosa invasion was 30.0% (6/20), much lower than that without serosa invasion (85.7%).
Conclusion: The multidrug resistance cells are present in primary gastric carcinomas prior to chemotherapy, and analysis of mdrl gene, MRP, LRP may have guiding significance in the treatment of gastric carcinoma.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1647}
}