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Bcl-2 GENE REARRANGEMENT DETERMINED BY PCR AS A MEAN TO DETECT MINIMAL RESIDUAL DISEASE IN MALIGNANT LYMPHOMAS

   
@article{CJCR1582,
	author = {Zhi-fu Xiang and Yu-ying Lu and Yong-rong Lai and Yan Chen and Hui-yu Li and Ping Zou},
	title = {Bcl-2 GENE REARRANGEMENT DETERMINED BY PCR AS A MEAN TO DETECT MINIMAL RESIDUAL DISEASE IN MALIGNANT LYMPHOMAS},
	journal = {Chinese Journal of Cancer Research},
	volume = {11},
	number = {1},
	year = {2013},
	keywords = {},
	abstract = {Objective: To develop a sensitive method to detect minimal residual disease and to elucidate the significance of bcl-2 gene rearrangement in diagnosis and treatment of malignant lymphoma. 
Methods: Using polymerase chain reaction (PCR) to detect bcl-2 gene rearrangement and using serial dilution method to define the sensitivity of PCR. 
Results: In 9 different malignant lymphoma cell lines, Su-DHL-4 and Su-DHL- 6 were shown bcl-2(MBR)/JH rearrangement, the sensitivity of PCR was 1:10 s. In 16 patients with follicular lymphoma, the peripheral blood and bone marrow were PCR positive in 4 cases both at initial diagnosis and after complete remission. 
Conclusion: Detection of bcl-2 gene rearrangement by PCR provides a sensitive and specific assay of minimal residual disease. It is helpful to improve staging of disease, prognosis and evaluation of the treatment results.},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/1582}
}