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EXPRESSION OF P16 AND CYCLIN D1 IN THE COURSE OF CARCINOGENESIS OF THE STOMACH

   
@article{CJCR1575,
	author = {Yu-long Chen and Feng Xu and Yan-jie Li},
	title = {EXPRESSION OF P16 AND CYCLIN D1 IN THE COURSE OF CARCINOGENESIS OF THE STOMACH},
	journal = {Chinese Journal of Cancer Research},
	volume = {11},
	number = {1},
	year = {2013},
	keywords = {},
	abstract = {Objective: To determine p16 and cyclin D1 expression in the specimen of gastric carcinoma, atypic hyperplasia, atrophic gastritis, superficial gastritis and normal gastric mucosa. 
Methods: Using immunohistochemical method (ABC), the samples of 58 adenocarcinomas, 22 atypic hyperplasias, 28 atrophic gastritis, 27 superficial gastritis and 15 gastric epitheliums were analyzed. 
Results: Positive immunostaining rate for p16 protein was the highest in normal gastric mucosa and decreased with the lesions progressing from superficial gastritis to atrophic gastritis to atypital hyperplasia and to adenocarcinoma (85 %, 78.6 %, 31.8 %, 48.3% respectively); Positive immunostaining of cycliLi D1 can observed in atrophic gastritis. With the lesions progressing from atrophic gastritis to atypical hyperplasia to adenocarcinoma, its expression rate increased (17.9 %, 36.4%, 53.4 % respectively), and there was a significant difference between adenocarcinoma and atrophic gastritis group (P},
	issn = {1993-0631},	url = {https://cjcr.amegroups.org/article/view/1575}
}