TY  - JOUR
AU  - Liu, Xiao-shan
AU  - Lou, Ling-sheng
AU  - Jiang, Ji-kai
AU  - Liu, Bei-zhong
AU  - Zhou, Jian-fang
AU  - Tang, Zong-shan
AU  - Li, Xue-xian
AU  - Kang, Ge-fei
PY  - 2013
TI  - INHIBITION OF TELOMERASE ACTIVITY DURING INDUCTION OF HL-60 CELLS BY RETINOID Ro13-7410
JF  - Chinese Journal of Cancer Research; Vol 11, No 1 (March 11, 1999): Chinese Journal of Cancer Research
Y2  - 2013
KW  - 
N2  - Objective: To investigate the effects of R013-7410 on telomerase activity and cell cycle distribution.   Methods: Telomerase activity of HL-60 cells induced by retinoid Ro13-7410 was detected by telomerase PCRELISA- kit. The cell cycle was analyzed by flow cytometry.   Results: Telomerase activity declined gradually after 10 .6 mol/L Ro13-7410 treatment, and the inhibition of telomerase activity at day 5 of treatment with Ro13- 7410 was less effective than with Retinoid Acid (RA). DNA flow cytofluorimetric analysis revealed that Ro13- 7410 caused partial cells arrest in the G2/M phase after 4-days treatment.   Conclusion: Telomerase activity declined gradually and partial cells were arrested in the G2/M phase after Ro13-7410 treatment.
UR  - https://cjcr.amegroups.org/article/view/1571