%0 Journal Article
%T INHIBITION OF TELOMERASE ACTIVITY DURING INDUCTION OF HL-60 CELLS BY RETINOID Ro13-7410
%A Liu, Xiao-shan
%A Lou, Ling-sheng
%A Jiang, Ji-kai
%A Liu, Bei-zhong
%A Zhou, Jian-fang
%A Tang, Zong-shan
%A Li, Xue-xian
%A Kang, Ge-fei
%J Chinese Journal of Cancer Research
%D 2013
%B 2013
%9 
%! INHIBITION OF TELOMERASE ACTIVITY DURING INDUCTION OF HL-60 CELLS BY RETINOID Ro13-7410
%K 
%X Objective: To investigate the effects of R013-7410 on telomerase activity and cell cycle distribution.   Methods: Telomerase activity of HL-60 cells induced by retinoid Ro13-7410 was detected by telomerase PCRELISA- kit. The cell cycle was analyzed by flow cytometry.   Results: Telomerase activity declined gradually after 10 .6 mol/L Ro13-7410 treatment, and the inhibition of telomerase activity at day 5 of treatment with Ro13- 7410 was less effective than with Retinoid Acid (RA). DNA flow cytofluorimetric analysis revealed that Ro13- 7410 caused partial cells arrest in the G2/M phase after 4-days treatment.   Conclusion: Telomerase activity declined gradually and partial cells were arrested in the G2/M phase after Ro13-7410 treatment.
%U https://cjcr.amegroups.org/article/view/1571
%V 11
%N 1
%P 16-18
%@ 1993-0631