@article{CJCR1571,
author = {Xiao-shan Liu and Ling-sheng Lou and Ji-kai Jiang and Bei-zhong Liu and Jian-fang Zhou and Zong-shan Tang and Xue-xian Li and Ge-fei Kang},
title = {INHIBITION OF TELOMERASE ACTIVITY DURING INDUCTION OF HL-60 CELLS BY RETINOID Ro13-7410},
journal = {Chinese Journal of Cancer Research},
volume = {11},
number = {1},
year = {2013},
keywords = {},
abstract = {Objective: To investigate the effects of R013-7410 on telomerase activity and cell cycle distribution.
Methods: Telomerase activity of HL-60 cells induced by retinoid Ro13-7410 was detected by telomerase PCRELISA- kit. The cell cycle was analyzed by flow cytometry.
Results: Telomerase activity declined gradually after 10 .6 mol/L Ro13-7410 treatment, and the inhibition of telomerase activity at day 5 of treatment with Ro13- 7410 was less effective than with Retinoid Acid (RA). DNA flow cytofluorimetric analysis revealed that Ro13- 7410 caused partial cells arrest in the G2/M phase after 4-days treatment.
Conclusion: Telomerase activity declined gradually and partial cells were arrested in the G2/M phase after Ro13-7410 treatment.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1571}
}