@article{CJCR1564,
author = {Xiao-xi Li and Hui-qian Wu and Guo-hua Zhao and Shen-ming Wang and Guo-rui Chen},
title = {RAS AND p53 EXPRESSION IN HUMAN THYROID CARCINOMA},
journal = {Chinese Journal of Cancer Research},
volume = {12},
number = {4},
year = {2013},
keywords = {},
abstract = {Objective: To investigate the possible interaction between the ras and p53 genes over-expression in thyroid carcinoma, and whether there is a correlation between the ras and p53 over-expression and clinicopathological criteria.
Methods: Eighty patients with thyroid lesions were examined for expression of ras and p53 genes by the labeled streptavidin biotin peroxidase (LSAB) method. Of these patients, 54 were diagnosed (average age: 39.9±15.9 years) with malignant lesions. Of those included in the study, 31 has papillary carcinoma, 13 had follicular carcinoma, 7 had medullary carcinoma, 3 had undifferentiated carcinoma and 19 were stratified to stage I, 28 to stage II, 2 to stage II! and 5 to stage IV according to TNM staging system. Twenty-six benign nodular thyroid disorders were studied as control.
Results: Positive immunostain results for ras and p53 genes were statistically significant between thyroid carcinomas and benign disorders (90.7% vs 23%, 55.5% vs 30.7%, P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1564}
}