@article{CJCR1540,
author = {Jie Wang and Xu-yi Liu and Xi-ping Li and Wei Jiang and Li Liang},
title = {THE CORRELATION BETWEEN THE EXPRESSION OF MULTIDRUG RESISTANCE RELATED GENE AND CELL APOPTOSIS AND CLINICAL SIGNIFICANCE IN NON-SMALL CELL LUNG CANCER},
journal = {Chinese Journal of Cancer Research},
volume = {12},
number = {4},
year = {2013},
keywords = {},
abstract = {Objective: To explore the correlation and clinical significance between expression of MDR (multidrug resistance) related gene MRP, MDRI, C-erbB-2 and cell apoptosis in non-small cell lung cancer (NSCLC).
Methods: RT-PCR, Immunohistochemistry were used to examine the expression of mRNA and protein in the MDR and apoptosis related gene. Apoptosis cells were assayed by Terminal deoxynucleotidyl transferase (TdT)- mediated biotin dUTP nick end-labeling (TUNEL).
Results: The positive rates of MRP, MDRI, C-erbB-2, bcl-2, C-myc mRNA in 63 cases NSCLC were 81.0% (51/63), 38.1%(24/63), 47.6 % (30/63), 65.1%(41/63), 76.2%(48/63) respectively. Their levels were higher than those of corresponding proteins (74.6%, 34.9%, 46.0%, 61.9%, 71.4%, respectively). The significant association was found between the mRNA level and the protein expression (r=+0.764, P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1540}
}