@article{CJCR1506,
author = {Jian-bo Yang and Xiao-mei Zhang and Long-wen Deng and Guo-lin Tan and Ming Zhou and Zhao-yang Zeng and Li Cao and Shou-rong Shen and Gui-yuan Li},
title = {DETAILED DELETION MAPPING OF CHROMOSOME 9p21-22 IN NASOPHARYNGEAL CARCINOMA},
journal = {Chinese Journal of Cancer Research},
volume = {12},
number = {3},
year = {2013},
keywords = {},
abstract = {Objective: To further refine the extent of deletion on chromosome 9p21-22 in nasopharyngeai carcinoma (NPC) and provide evidence for discovering new tumor suppressor gene.
Methods: Loss of heterozygosity (LOH) on chromosome 91)21--22 was analyzed in 25 paired blood and tumor samples by using 11 high-density microsatellite polymorphic markers.
Results: 17 of 25 cases (68.0%) showed LOH at one or more loci. Higher frequencies of LOH were found at four loci: D9S161 (35.0%), D9S1678 (31.5%), D9S263 (33.3%) and D9S1853 (33.3%), where 6 cases had a contiguous stretch of allelic loss.
Conclusion: The minimal common region of deletion might be defined between D9S161 and D9S1853 (estimated about 2.7 cM in extent) at 9p21.1, suggesting that inactivation of one or more tumor suppressor genes located in this region may be an important step in NPC.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1506}
}