@article{CJCR1501,
author = {Yan Li and Guo-liang Yang and Hong-yin Yuan and De-jiao Bai and Kun Wang and Yan Wang},
title = {EFFECTS OF PERIOPERATIVE CIMETIDINE ADMINISTRATION ON TUMOR CELL NUCLEAR MORPHOMETRY AND DNA CONTENT IN PATIENTS WITH GASTROINTESTINAL CANCER},
journal = {Chinese Journal of Cancer Research},
volume = {12},
number = {2},
year = {2013},
keywords = {},
abstract = {Objective: To explore the effects of perioperative cimetidine administration on tumor cell nuclear morphometric parameters and DNA content in patients with gastrointestinal adenocarcinoma.
Methods: 49 patients with pathologically confirmed gastrointestinal adenocarcinoma were randomized into test group (n=25) and control group (n=24). The test group started oral cimetidine intake 400 mg, tid, 7-10d before operation, followed by standard curative operation. The control group did not receive cimetidine. Tumor specimens were paraffin embedded for microsection and stained with hematoxylin and eosin (HE) and Feulgen stain. Morphometric studies and DNA content of tumor nuclei were performed on IBAS Image Analyzer.
Results: The tumor cell nuclear area (Ixrn2), nuclear perimeter (IJJn), maximal nuclear diameter (l~m) for test group/control group were 23.54 ~.5.08/34.69-&10.08 (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1501}
}