@article{CJCR1475,
author = {Ru-gang Zhang and Jin-hui Yuan and Xing-wang Wang and Bin Xu and Hong Xie},
title = {TELOMERASE: A NOVEL TARGET OF ANTITUMOR AGENTS},
journal = {Chinese Journal of Cancer Research},
volume = {12},
number = {1},
year = {2013},
keywords = {},
abstract = {Telomerase activity was found to be high in various human cancers, but absent in most normal tissues. Its expression pattern made it a novel target for antitumor agents. Several strategies against telomerase were presented in this review. Targeting the telomerase RNA component by oligonucleotide/ribozyme was considered to be one of the most hopeful approaches. Some progresses were made in this area, such as the use of PANs and 2-5A antiseuse compounds. The relationships among telomerase activity and cell differentiation, signal trausduction, oncogene, tumor suppressor gene as well as cell cycle modulation also provided a series of valuable ideas in designing anti-telomerase drugs for cancer therapy. In conclusion, although there is still a long way in understanding the mechanism and regulation of telomerase, the advance of studies on telomerase has allowed the development of numerous strategies for the treatment of cancer.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1475}
}