TY  - JOUR
AU  - Chen, Zhong-ping
AU  - Pan, Jun
AU  - Huang, Qiang
AU  - Sun, Zhi-fang
AU  - Zhou, Li-ying
AU  - Wang, Ai-dong
AU  - Panasci, Lawrence C.
PY  - 2013
TI  - ANTITUMOR EFFECT OF SARCNU IN A 06-METHYLGUANINE-DNA METHYLTRANSFERASE POSITIVE HUMAN GLIOMA XENOGRAFT MODEL
JF  - Chinese Journal of Cancer Research; Vol 12, No 1 (March 19, 2000): Chinese Journal of Cancer Research
Y2  - 2013
KW  - 
N2  - Objective: To assess whether novel analogue of    nitrosoureas, 2-chloroethyl-3-sarcosinamide- 1-nitrosourea    (SarCNU), has antitumor effect to 06-methylguanine-DNA    methyltransferase (MGMT) positive tumors in vivo.    Methods: MGMT positive human glioma cell line SF-767    xenografts in nude mice were treated with SarCNU. The    antitumor efficacy of SarCNU was compared with the    results of 1, 3-bis(2-chloroethyl)-l-nitrosourea (BCNU)    treatment with or without 06-benzylguanine (06-BG)    preadministration.     Results: Since the SF-767 is MGMT    strongly positive, BCNU treatment alone did not result in a    satisfactory anticancer effect. As expected, 06-BG by    depleting MGMT activity, significantly enhanced BCNU    antltumor efficacy (P
UR  - https://cjcr.amegroups.org/article/view/1460