@article{CJCR1460,
author = {Zhong-ping Chen and Jun Pan and Qiang Huang and Zhi-fang Sun and Li-ying Zhou and Ai-dong Wang and Lawrence C. Panasci},
title = {ANTITUMOR EFFECT OF SARCNU IN A 06-METHYLGUANINE-DNA METHYLTRANSFERASE POSITIVE HUMAN GLIOMA XENOGRAFT MODEL},
journal = {Chinese Journal of Cancer Research},
volume = {12},
number = {1},
year = {2013},
keywords = {},
abstract = {Objective: To assess whether novel analogue of
nitrosoureas, 2-chloroethyl-3-sarcosinamide- 1-nitrosourea
(SarCNU), has antitumor effect to 06-methylguanine-DNA
methyltransferase (MGMT) positive tumors in vivo.
Methods: MGMT positive human glioma cell line SF-767
xenografts in nude mice were treated with SarCNU. The
antitumor efficacy of SarCNU was compared with the
results of 1, 3-bis(2-chloroethyl)-l-nitrosourea (BCNU)
treatment with or without 06-benzylguanine (06-BG)
preadministration.
Results: Since the SF-767 is MGMT
strongly positive, BCNU treatment alone did not result in a
satisfactory anticancer effect. As expected, 06-BG by
depleting MGMT activity, significantly enhanced BCNU
antltumor efficacy (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1460}
}