@article{CJCR1380,
author = {Zhitao Ying and Xuejuan Wang and Yuqin Song and Wen Zheng and Xiaopei Wang and Yan Xie and Ningjing Lin and Meifeng Tu and Lingyan Ping and Weiping Liu and Lijuan Deng and Chen Zhang and Zhi Yang and Jun Zhu},
title = {Prognostic value of interim 18F-FDG PET/CT in diffuse large B-cell lymphoma},
journal = {Chinese Journal of Cancer Research},
volume = {25},
number = {1},
year = {2013},
keywords = {},
abstract = {Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim 18F-FDG PET/CT after first-line treatment in patients with DLBCL.
Methods: Thirty-two patients with DLBCL underwent baseline, interim and post-treatment 18F-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively.
Results: Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim 18F-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival (PFS) rates were significantly different between the groups above and below SUVmax cut-off value of 2.5 (P=0.039). No significant differences were found in the 2-year PFS rates if SUVmax cut-off values were set as 2.0 and 3.0, respectively (P=0.360; P=0.113).
Conclusions: Interim PET/CT could predict the prognosis of DLBCL patients with the SUVmax cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion.},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/1380}
}