TY  - JOUR
AU  - Lv, Dong
AU  - Cui, Pei-Lin
AU  - Yao, Shi-Wei
AU  - Xu, You-Qing
AU  - Yang, Zhao-Xu
PY  - 2012
TI  - Melatonin inhibits the expression of vascular endothelial growth factor in pancreatic cancer cells
JF  - Chinese Journal of Cancer Research; Vol 24, No 4 (December 07, 2012): Chinese Journal of Cancer Research
Y2  - 2012
KW  - 
N2  - Objective: To investigate the effects of melatonin on cellular proliferation and endogenous vascular endothelial growth factor (VEGF) expression in pancreatic carcinoma cells (PANC-1).  Methods: PANC-1 cells were cultured for this study. The secreted VEGF concentration in the culture medium was determined using ELISA method, VEGF production in the tumor cells was detected by immunocytochemistry, and VEGF mRNA expression was determined by RT-PCR.  Results: Higher melatonin concentrations significantly inhibited cellular proliferation, with 1 mmol/L concentration exhibiting the highest inhibitory effect (P
UR  - https://cjcr.amegroups.org/article/view/1115